Liposomes with Caffeic Acid: Morphological and Structural Characterisation, Their Properties and Stability in Time

Medical and pharmaceutical research has shown that liposomes are very efficient in transporting drugs to targets. In this study, we prepared six liposome formulas, three which entrapped caffeic acid (CA), with only phospholipids without CA. Determination of entrapment efficiency (EE) showed regardless the used, percentage CA was up 76%. The characterization performed using Dynamic Light Scattering (DLS), Atomic Force Microscopy (AFM), zeta potential polydispersity about 75–99% had dimensions between 40 ± 0.55–500 1.45 nm. size were influenced by type phospholipid used obtain them. release from a six-cell Franz diffusion system, it observed occurs gradually, highest amount occurring first eight hours (over 80%), after is much reduced. Additionally, time stability obtained analysed univariate multivariate statistical analysis. Therefore, offer great entrapment.